Advantages of our wound care solution in comparison to chemical substances

It contains the preservatives sodium hypochlorite and hypochlorous acid which ensure the product’s sterility. These compounds are naturally produced as defensive agents by mammalian neutrophils/monocytes as part of the immune system.

Great Efficacy

The primary mode of action involves the mechanical removal of cellular debris, senescent cells, necrotic tissue, and foreign material from the skin and wound surface using a moistened dressing (e.g.gauze) along with irrigation. Removal of these materials through these actions is known to decrease infection rates and improve wound healing. The secondary mode of action is a function of the antimicrobial properties of hypochlorous acid (HOCl) and its salt, hypochlorite (OCl^–) (1). These ancillary medicinal substances which are present in very low, non toxic amounts, assist in the removal of microorganisms.

• Can remain in the wound and does not need to be rinsed out
• Can also be used in exposed joints, cartilage, ligaments, and tendons
• Does not develop bacterial resistance

Maximum Tolerance

The essential component is hypochlorous acid (HOCl). It is an important constituent of our innate immune system and is formed and released by the macrophages during phagocytosis. This represents a significant advantage over other wound-irrigation and antiseptic solutions as highly organized cell structures such as human tissue can tolerate the action of our Wound Care solution while single-celled microorganisms cannot.

• No known side effects on human cells
• Not cytotoxic

Low Irritation Threshold

It is tolerated extremely well and has achieved an irrigation threshold of 1.022 in the HET-CAM assay.

Due to its unique chemistry, our Wound treatment solution is much more stable than similar products on the market and therefore maintains much higher levels of hypochlorous acid over its shelf life.
It is ideal for use in exposed joints, tendons, bones, and ligaments. In addition, it is possible to use it for installation in negative-pressure wound therapy and in peritoneal and joint irrigation.

The preservatives in MicrocynRX® Wound Care, (hypochlorous acid and sodium hypochlorite), guarantee product sterility due to their outstanding anti-microbial characteristics.
MicrocynRX® Wound Care eliminates unpleasant wound odors in just a few seconds.
The MicrocynRX® Wound Care effect has also been proven under clinical conditions: in a controlled prospective-study*, 90% of patients had a distinct increase in granulation and improvement in the surrounding skin.
*Martínez-De Jesús FR, Ramos-De la Medina A, Remes-Troche JM, Armstrong DG, Wu SC, Lázaro Martínez JL, Beneit-Montesinos JV.
Efficacy and safety of neutral pH superoxidised solution in severe diabetic foot infections. Int Wound J 2007;doi:10.1111/j.1742-481X.2007.00363.x.

MicrocynRX® Wound Care is effective against gram-positive and gram-negative bacteria (including MRSA), viruses, fungi, and spores.

CATEGORIE	MICROORGANISM	STANDARD / METHOD	TYPE	Expos. Time (Minutes)	Reduction of Microbial Load
Bactericide	Pseudomonas aeruginosa	AOAC Use Dilution Method BS EN 13727:1999	Carrier / Suspension	10 / 15	> 4,7 log / > 5,4 log
	Staphylococcus aureus	AOAC Use Dilution Method BS EN 13727:1999	Carrier / Suspension	10 / 15	> 4,7 log / > 5,1 log
	Salmonella choleraesuis	AOAC Use Dilution Method	Carrier	10	> 5,7 log
	Enterococcus hirae	BS EN 13727:1999	Suspension	15	> 5,0 log
	Escherichia coli	AOAC Use Dilution Method	Carrier	1	> 5,0 log
Bactericide (resistant strains)	Methicillinresistente Staphylococcus aureus (MRSA)	AOAC Use Dilution Method	Carrier	10	> 5,9 log
	Vancomycinresistente Enterococcus faecalis (VRE)	AOAC Use Dilution Method	Carrier	10	> 6,1 log
Tuberculocide	Mycobacterium bovis	Tuberculocidal effect in suspension	Suspension	5	> 6,4 log
Virucide	Human Immundeficiency Virus Type I (HIV-I)	As U.S. EPA guidelines	Carrier	10	> 3,7 log
Fungicide	Trichophyton mentagrophytes	Fungicidal Use Dilution Method	Carrier	10	> 6,3 log
Sporicide	Bacillus atrophaeus	BS EN 14347:2002	Suspension	15	> 6,5 log

In vitro study also available under: Journal of Hospital Infection (2005), 1–9: Dr. Landa-Solis

More than five million patients have been treated worldwide with MicrocynRX® Wound Care. In Europe, the USA, Mexico, China, India, and Malaysia, more than 40 clinical studies have been conducted—all this without any indication of irritation, sensitization, toxicity or eye irritation.

Wound Treatment Solution
There are many cleansers with the ability to kill microorganisms. Unfortunately, many of these cleansers are antiseptics with a high degree of toxicity and will therefore destroy the surrounding skin and peri-wound tissue.
While fighting infections these antiseptics will in fact inhibit wound healing!
Therefore it has never been our isolated goal to fight infections only. Microdacyn60 is not just another anti-microbial cleanser but a ‘Wound Treatment Solution’.
Our focus is to heal wounds as quickly as possible. In order to achieve, effectivity and safety (non-toxicity) must be united. Microdacyn60 may therefore not be labelled the strongest “antimicrobial” product, but the use of natural body ingredients (in fact the same ingredients that our body immune system uses) will speed up the healing process by stimulating the body to perform its own healing process.
Physical mode of action
What also makes MicrocynRX® different is a physical mode of action instead of a chemical mode of action. Again, many antiseptics contain chemical ingredients and kill by chemical action (which in fact also is a source of bacterial resistance).
While MicrocynRX® ’s active ingredient (Hypochlorous Acid) increases microorganisms’ cell wall permeability by denaturing proteins and fatty acids, it does not kill microorganisms!

What destroys microorganisms is induced by a purely natural and physical process called Osmosis. Osmosis is the tendency of water to flow from a low concentration of salt (HYPOTONIC) to a high concentration of salt (HYPERTONIC).

The concentration of salt (NaCl) in bacteria (0,9%) is 33x higher than the concentration of salt in MicrocynRX® (0,027%). When a single cell organism gets in contact with hypotonic MicrocynRX® , the water molecules will move into the microorganism causing it to swell. The combination of excessive swelling and the increased cell wall permeability will cause cell lysis and -instantly- kill the microorganism.
The lower the Osmolality, the stronger the Osmotic pressure and the stronger the physical effect on microorganisms. With an Osmolarity of only 13  mOsmol/kg, MicrocynRX® is the most powerful hypotonic HOCl solution on the market today.

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Rinse the wound with MicrocynRX® Wound Care and let it take effect briefly; the process can be repeated up to three times daily or whenever the bandage is changed. Alternatively, the wound can also be cleaned with compresses soaked in MicrocynRX® Wound Care. Adhering bandages can be loosened easily and without trauma using MicrocynRX® Wound Care. To support mechanical wound cleansing, the working time of MicrocynRX® Wound Care can be extended to 15 minutes.

Practical info

• Microdacyn60® Wound Care is a ready-to-use, pH-neutral wound-irrigation solution
• pH value 7.0
• Shelf life of up to 24 months at room temperature if not open
• Use within 60 days after opening
• Can be warmed before use with no problems (to 40°C)